Lipoic Acid: Universal Antioxidant Helps Boost Glutathione Levels

Most nutritional compounds which exhibit antioxidant properties are either water-soluble or fat-soluble. But sulfur-containing alpha-lipoic acid, the “universal antioxidant”, is capable of producing its effects both in aqueous and lipophilic environments.

Widely considered one of the most important conditionally essential nutrients, alpha-lipoic acid (also known as Lipoic Acid, ALA, or LA for short) is found in every cell of the human body. It has the ability to recycle and regenerate other antioxidants-notably vitamin C, vitamin E and glutathione-and provides researched anti-inflammatory activity, independent of its antioxidant properties.

A significant benefit of alpha-lipoic acid is its researched ability to help increase reduced glutathione levels both in vitro and in vivo. As perhaps our most vital endogenous antioxidant, sulfur-containing glutathione is absolutely critical for proper immune system function, Phase 2 liver detoxification, ocular health, and countless other physiologic mechanisms and processes. However, because glutathione is naturally produced in living bodies, it is difficult to manufacture an isolated glutathione supplement that is stable, well-absorbed and effective.

The ability of lipoic acid to boost glutathione levels may begin to explain the reported ability of ALA to help promote healthy liver detox, chelate mercury and heavy metals, speed recovery after exercise and support healthy skin, eyes, blood vessels, nervous system structure/function, and more.

In addition, ALA has been extensively researched to help support healthy insulin sensitivity, promote the uptake of glucose by cells, and reduce glycation end products that lead to accelerated aging. Lipoic acid is often recommended for patients with issues of blood sugar dysregulation, and is considered one of the most important nutrients for supporting peripheral nerve health related to poor glycemic control. Safety and efficacy in delaying or reversing neuropathic symptoms has been consistently reported at doses of 600 mg ALA per day, while lower amounts may be used for the support and maintenance of numerous body systems.

[And… in BOX with PIC OF PRODUCT (not in pdf version)]

Moss Nutrition Lipoic Acid provides 300 mg of researched, “universal antioxidant” alpha-lipoic acid per vegetarian cellulose capsule.

By Diana Allen, MS, CNS, Product Development Manager

Moss Nutrition Digest #10 – 03/20/2019 – PDF Version

Lipoic Acid: Universal Antioxidant Helps Boost Glutathione Levels


  1. Moura FA, et al. Lipoic Acid: its antioxidant and anti-inflammatory role and clinical applications. Curr Top Med Chem. 2015;15(5):458-83.
  2. Busse E, et al. Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo. Arzneimittelforschung. 1992 Jun;42(6):829-31.
  3. Negrişanu G, et al. Effects of 3-month treatment with the antioxidant alpha-lipoic acid in diabetic peripheral neuropathy. Rom J Intern Med. 1999 Jul-Sep;37(3):297-306.
  4. Vallianou N, et al. Alpha-lipoic Acid and diabetic neuropathy. Rev Diabet Stud. 2009 Winter;6(4):230-6.